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  • Title: Role for the amino-terminal region of human TBP in U6 snRNA transcription.
    Author: Mittal V, Hernandez N.
    Journal: Science; 1997 Feb 21; 275(5303):1136-40. PubMed ID: 9027316.
    Abstract:
    Basal transcription from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc). TBP consists of a conserved carboxyl-terminal domain that performs all known functions of the protein and a nonconserved amino-terminal region of unknown function. Here, the amino-terminal region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAPc to the U6 promoter, and enhance U6 transcription.
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