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  • Title: [Enzymatic assessment of the area of necrosis. I. Diagnosis and quantitative evaluation of acute myocardial infarct by means of MB creatine kinase isoenzyme. Comparison with deduced from creatine kinase activity].
    Author: Menozzi C, Ferretti P, Guiducci U, Bruno G, Casali G.
    Journal: G Ital Cardiol; 1977; 7(7):677-84. PubMed ID: 902947.
    Abstract:
    On the purpose of specifying more and more the peculiarity of the isoenzymes MBCK in regard to enzyme CK, in the diagnosis as well as in the quantitative evaluation of myocardial infarction, we examined 34 patients hospitalized in U.C.I.C. The curves of the MBCK and CK were obtained through samples taken every 2-3 hours still the 12th hour, after the enzymatic concentration have exceeded the normal level and successively every 4 hours till the enzymatic activity regains its limits. The values of I.S.MBCK and I.S.CK were compared and we obtained two correlations based on the enteric work (r = 0.79) or on selected cases (r = 0.96). We conclude, for the major practicality and usefulness of measurement of MBCK in the evaluation of size, because this measurement can be obtained on the total enumeration of cases of myocardial infarction, not takine into consideration all those factors which could produce an increase of CK; moreover the MBCK is able to show the extension of myocardial infarction that would not be detectable with CK.
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