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  • Title: NMDA receptor 2C subunit is selectively decreased by MK-801 in the entorhinal cortex.
    Author: Lindén AM, Väsäinen J, Wong G, Castrén E.
    Journal: Eur J Pharmacol; 1997 Jan 14; 319(1):R1-2. PubMed ID: 9030910.
    Abstract:
    Administration of the non-competitive NMDA receptor antagonist MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[1,d]cyclohepten-5,10-imine) produces paradoxical neurotoxicity in limbic cortical regions which includes the entorhinal cortex. The expression of NMDAR-2C but not -2A, -2B or -2D subunits was significantly decreased in rat entorhinal cortex layer III following MK-801 administration. These results suggest an important role for the NMDAR-2C subunit in the response to MK-801-induced neurotoxicity in brain regions highly vulnerable to injury.
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