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  • Title: Synthesis and antibacterial activity of derivatives of the glycopeptide antibiotic A-40926 and its aglycone.
    Author: Hermann R, Ripamonti F, Romanò G, Restelli E, Ferrari P, Goldstein BP, Berti M, Ciabatti R.
    Journal: J Antibiot (Tokyo); 1996 Dec; 49(12):1236-48. PubMed ID: 9031670.
    Abstract:
    Starting from the antibiotic A-40926 and the aglycone of A-40926 a series of compounds were prepared by modifying the free functionalities. Their antimicrobial activity was determined, particularly against Neisseria gonorrhoeae, against which A-40926, unlike other natural glycopeptides, is active. Improved in vivo activity was displayed by the monomethyl ester of A-40926 esterified at the carboxyl group of the N-acylamino-glucuronyl moiety.
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