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  • Title: Prevention of NSAID-gastropathy.
    Author: Ardizzone S, Bianchi Porro G.
    Journal: Ital J Gastroenterol; 1996 Dec; 28 Suppl 4():33-6. PubMed ID: 9032581.
    Abstract:
    The role is reviewed of gastric antisecretory and mucosal protective drugs in the prevention of NSAID-induced gastric and duodenal mucosal lesions. The results of the randomized, double-blind, controlled trials show that misoprostol is the only antiulcer drug proven to be effective in the prevention of NSAID-induced gastric and duodenal ulcers as well as for reducing serious upper gastrointestinal complications (perforation and/or haemorrhage). However, recent data suggest that even omeprazole and high dose of H2-receptor antagonists may have a role in the prevention of NSAID-induced gastric and duodenal ulcerations.
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