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  • Title: A role for DNA primase in coupling DNA replication to DNA damage response.
    Author: Marini F, Pellicioli A, Paciotti V, Lucchini G, Plevani P, Stern DF, Foiani M.
    Journal: EMBO J; 1997 Feb 03; 16(3):639-50. PubMed ID: 9034345.
    Abstract:
    The temperature-sensitive yeast DNA primase mutant pri1-M4 fails to execute an early step of DNA replication and exhibits a dominant, allele-specific sensitivity to DNA-damaging agents. pri1-M4 is defective in slowing down the rate of S phase progression and partially delaying the G1-S transition in response to DNA damage. Conversely, the G2 DNA damage response and the S-M checkpoint coupling completion of DNA replication to mitosis are unaffected. The signal transduction pathway leading to Rad53p phosphorylation induced by DNA damage is proficient in pri1-M4, and cell cycle delay caused by Rad53p overexpression is counteracted by the pri1-M4 mutation. Altogether, our results suggest that DNA primase plays an essential role in a subset of the Rad53p-dependent checkpoint pathways controlling cell cycle progression in response to DNA damage.
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