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  • Title: [Prediction of the central effect of pharmacological preparations in a hyperbaric environment].
    Author: Sledkov AI.
    Journal: Aviakosm Ekolog Med; 1996; 30(6):24-6. PubMed ID: 9035793.
    Abstract:
    A new method for predicting the central effects of pharmacological preparations in hyperbaric helio- and nitrogen-oxygen environments takes into consideration the dynamics of changes in excitability of different structures of the brain in animals compared with EEG and behavioural symptoms of the high pressure nervous syndrome (HPNS), and levels of the barometric pressure. The concept of the central effect of preparations under hyperbaric conditions should be taken into account while rendering the medicamentous assistance to aquanauts directly exposed to elevated pressure. Besides, it was shown that the strategy of searching protectors against NSHP and nitrogen narcosis may consist of selecting substances which will adequately recuperate shifts in the brain excitability due to these hyperbaric pathologies.
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