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  • Title: Evolution of left ventricular hypertrophy and function during long-term treatment of systemic hypertension with enalapril.
    Author: González-Juanatey JR, Pose Reino A, Román AV, García Acuña JM, Fernández López JA, Cerrato JC.
    Journal: Am J Cardiol; 1997 Feb 01; 79(3):373-6. PubMed ID: 9036764.
    Abstract:
    Continued treatment of hypertensive patients with enalapril reduced left ventricular (LV) hypertrophy steadily over a period of 5 years (by which time gross structural parameters were normal) and produced no further reduction during the following 2 years. Temporary suspension of treatment after 5-year follow-up gave rise to an increase in blood pressure, and to deterioration of LV isovolumic relaxation time and deceleration of the ventricular filling E wave, both of which chiefly reflect the active relaxation of the ventricle.
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