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  • Title: Mutation in ntrC gene leading to the derepression of nitrogenase synthesis in Rhodobacter sphaeroides.
    Author: Zinchenko V, Babykin M, Glaser V, Mekhedov S, Shestakov S.
    Journal: FEMS Microbiol Lett; 1997 Feb 01; 147(1):57-61. PubMed ID: 9037764.
    Abstract:
    The Rhodobacter sphaeroides mutants Drn12 and Drn21 derepressed for nitrogenase synthesis in the presence of ammonia and impaired in utilization of certain nitrogen sources have been analyzed. Both mutants show a low level of expression of the glnBA operon. The DNA fragment restoring the wild-type phenotype to these mutants contains the 3'-portion of ntrB gene and the entire ntrC gene. Sequence analysis showed that Drn12 bears a missense mutation in the ntrC gene. The mutation results in the replacement of a glycine residue by aspartate within the N-terminal domain of the NtrC protein. Pleiotropic phenotypes of Drn12 and Drn21 appear to be associated with an alteration in the regulation of glnBA expression.
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