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  • Title: Gadopentetate dimeglumine and iodinated contrast media. Hemodynamic side effects after bolus injections in pigs.
    Author: Kuhtz-Buschbeck JP, Ehrhardt K, Köhnlein S, Radtke W, Heintzen P.
    Journal: Invest Radiol; 1997 Feb; 32(2):111-9. PubMed ID: 9039584.
    Abstract:
    RATIONALE AND OBJECTIVES: The use of bolus injections of contrast media containing gadolinium for magnetic resonance imaging and their potential use as x-ray absorbents require the evaluation of possible cardiovascular side effects. The hemodynamic reactions of high doses (0.6 mmol/ kg) of gadopentetate dimeglumine (gadolinium [Gd]-DTPA, Magnevist) were evaluated and compared with the side effects of ionic (diatrizoate: Urografin 76%) and nonionic (iopamidol, Solutrast 370) radiographic contrast media. METHODS: In 18 pigs, pressure and flow of the systemic and pulmonary circulation were monitored after intracardiac bolus injections (2-4 seconds) of dose volumes of 1.2 mL/kg of each contrast agent. RESULTS: All contrast media decreased the aortic pressure transiently (Gd-DTPA and diatrizoate: -25%, iopamidol: -10%; P < 0.01). Pulmonary artery pressure, cardiac output, and stroke volume increased for several minutes. The vascular resistance declined. Diatrizoate induced stronger and longer-lasting side effects (P < 0.01) than Gd-DTPA and iopamidol. CONCLUSIONS: Despite of similar osmolality, Gd-DTPA induced weaker side effects than equivolumetric applications of diatrizoate. Other than osmolality, other factors such as viscosity and chemotoxicity influence the side effects of contrast media.
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