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  • Title: [Streptococcus pyogenes: in vitro susceptibility to several antimicrobials in two date periods].
    Author: Giglio MS, Robles M, Rioseco ML, Vidal A, Segovia L.
    Journal: Rev Med Chil; 1996 Jun; 124(6):715-9. PubMed ID: 9041729.
    Abstract:
    BACKGROUND: The frequency of Streptococcus pyogenes infections with deep tissue invasion and toxic shock syndrome has increased in the last decade throughout the world. AIM: To compare antimicrobial susceptibility of S. pyogenes strains isolated during 1986 and during 1994-95. MATERIAL AND METHOD: Eighty two S. pyogenes strains isolated in 1986 and 67 strains isolated in 1994-95, were studied. MIC 50 and 90 were determined by and agar dilution method for penicillin, ampicillin, cefazolin, cefuroxime, erythromycin, roxithromycin and miocamycin. RESULTS: Eighty eight strains came from skin of soft tissues, 19 from surgical wounds, 18 from invasive infections, 15 from pharyngeal swabs and 9 from other locations. All strains were susceptible to penicillin, ampicillin, cefazolin, cefuroxime, roxithromycin and miocamycin. Ninety nine percent of strains were susceptible to erythromycin. Strains isolated in 1995-95 had a higher MIC 50 and 90 for erythromycin than those isolated in 1986. CONCLUSIONS: The changes in susceptibility to erythromycin of recently isolated strains could be due to the widespread use of macrolides in Chile.
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