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  • Title: Respective role of TNF receptors in the development of experimental cerebral malaria.
    Author: Lucas R, Lou JN, Juillard P, Moore M, Bluethmann H, Grau GE.
    Journal: J Neuroimmunol; 1997 Feb; 72(2):143-8. PubMed ID: 9042106.
    Abstract:
    The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. The protection of Tnfr2null mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.
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