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  • Title: Atypical fibroxanthoma. An unusual variant with osteoclast-like giant cells.
    Author: Tomaszewski MM, Lupton GP.
    Journal: Am J Surg Pathol; 1997 Feb; 21(2):213-8. PubMed ID: 9042289.
    Abstract:
    We report three cases of an unusual variant of atypical fibroxanthoma with numerous multinucleated osteoclast-like giant cells. Histologically, the lesions were composed of uniformly dispersed multinucleated osteoclast-like giant cells within a pleomorphic cellular proliferation with microscopic and histochemical features of atypical fibroxanthoma. Multinucleated osteoclast-like giant cells, however, stained with KP-1, a macrophage-associated antigen only. These cells are not necessarily an integral part of the tumor and may represent a reactive histiocytic component.
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