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  • Title: The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes.
    Author: Leung MY, Fung KP, Choy YM.
    Journal: Immunopharmacology; 1997 Jan; 35(3):255-63. PubMed ID: 9043939.
    Abstract:
    Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro.
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