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  • Title: [Effect of the calcium antagonist amlodipine on non-vascular smooth muscle exemplified by the uterus].
    Author: Lechner W, Bergant A, Sölder E, Kölle D.
    Journal: Wien Med Wochenschr; 1996; 146(17):466-8. PubMed ID: 9045529.
    Abstract:
    The effect of amlodipine, a recently developed calciumantagonist on 21 uterine strips was investigated. Uterine activity, expressed by the area under the curve was depressed from 504 (51 to 1056) mm2 to 0 (0 to 130) 10 min after the application of amlodipine. After 20 and 60 min, the values were 0 (0 to 1310) and 0 (0 to 317) (median, 10th and 90th percentile). The decrease of uterine activity was highly significant (p < 0.0001). In summary, amlodipine exhibits a prompt and excellent relaxation on the spontaneous contractions of uterine strips.
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