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  • Title: [Nephrotic syndrome as the initial symptom of Crohn disease].
    Author: Kullmann F, Kullmann M, Leser HG, Krämer BK, Riegger AJ, Schölmerich J.
    Journal: Z Gastroenterol; 1996 Nov; 34(11):757-62. PubMed ID: 9045538.
    Abstract:
    In february 1993, a now 54-year-old man presented with an increased serum-creatinine of 1.7 mg/dl known since september 1992 associated with peripheral edema. He reported painless and infrequent diarrhea during the previous 15 years. Clinically, he showed typical symptoms of a nephrotic syndrome. A renal biopsy revealed an amyloidosis. By further investigations the diagnosis of underlying Crohn's disease could be established. An ileocecal resection and a subsequent immunosuppressive therapy with azathioprine was performed. Following this procedure the serum-creatinine has meanwhile increased to 3.2 mg/dl with the proteinuria remaining stable. Furthermore, the patient developed a renal hypertension. However, at present the patient is otherwise asymptomatic and in a good general condition.
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