These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Block in anaphase chromosome separation caused by a telomerase template mutation. Author: Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH. Journal: Science; 1997 Mar 07; 275(5305):1478-81. PubMed ID: 9045613. Abstract: Telomeres are essential for chromosome stability, but their functions at specific cell-cycle stages are unknown. Telomeres are now shown to have a role in chromosome separation during mitosis. In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase. The mutant chromatids failed to separate completely at the midzone, becoming stretched to up to twice their normal length. These results suggest a physical block in mutant telomere separation.[Abstract] [Full Text] [Related] [New Search]