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  • Title: Can a double isotope method be used to measure fractional zinc absorption from urinary samples?
    Author: Rauscher A, Fairweather-Tait S.
    Journal: Eur J Clin Nutr; 1997 Feb; 51(2):69-73. PubMed ID: 9049563.
    Abstract:
    OBJECTIVE: This study was designed to test whether fractional absorption calculated from urinary enrichment of stable isotopes of zinc accurately reflects true absorption measured by faecal monitoring. DESIGN: The two techniques were directly compared in volunteers, whereby each subject acted as his/her own control. SETTING: Volunteers were healthy adults, living at home, who were taking part in a larger study on zinc. They attended the local hospital for isotope administration. SUBJECTS: Fifteen volunteers were recruited, seven of whom had non-insulin dependent diabetes mellitus. All completed the study, but five did not carry out a complete faecal collection. INTERVENTIONS: Each subject received an oral and i.v. dose of different stable isotopes of zinc with breakfast. Faecal and urinary enrichment with the isotopes was measured. RESULTS: There was no significant correlation between the two measures of absorption. CONCLUSIONS: The double label stable isotope technique for determining zinc absorption from measurements of urinary enrichment does not reliably predict true zinc absorption (measured by faecal and urinary monitoring) in a heterogenous group of adults given relatively low doses of stable isotopes of zinc.
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