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  • Title: Effect of methionine on the brain biogenic monoamines and on the cortical bioelectrical activity of rabbits.
    Author: Kleinrok Z, Przegaliński E, Lasarova M, Roussinov KS, Sokolov V.
    Journal: Pol J Pharmacol Pharm; 1977; 29(4):377-84. PubMed ID: 905205.
    Abstract:
    Methionine (150 and 300 mg/kg ip for 3 days) did not change the concentrations of striatal DA. It was also without effect on the levels of NA and 5-HT in the diencephalon and in the brain stem, while the 5-HIAA content was significantly increased in both structures after the dose 300 mg/kg. The single injection of methionine in doses of 10--300 mg/kg iv provoked dose-dependent changes in cortical bioelectrical activity. It was observed a considerable increase in the number of spindles, an increase in the amplitude and number of waves composing the spindles as well as a rise in their frequency characteristic.
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