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  • Title: [Optimization of the diagnosis and treatment of anemias under exposure to aromatic-type organic solvents].
    Author: Shpagina LA, Loseva MI, Sukharevskaia TM, Sharapov VI, Sazonova OV, Tret'iakov SV.
    Journal: Ter Arkh; 1996; 68(12):15-9. PubMed ID: 9054029.
    Abstract:
    171 iron-deficient painters and 20 subjects with chronic intoxication with aromatic hydrocarbons were studied in a large aircraft construction factory. After correlative analysis of iron metabolism, ferritin, erythrocytes, diameter and perimeter of reticulocytes, length of service three types of iron-deficiency were identified: typical, with evident toxicity, with a high risk of toxic damage. An important role of lipid peroxidation activity and toxic erythrocyto-membranopathy for pathomorphosis of iron deficiency anemia and progress of toxic anemia is demonstrated. A differential approach to treatment of different anemia variants was used. The treatment included membranoprotectors (alpha-tocopherol, essential, lypostabil) and unspecific detoxication (SUMS-enterosorbent, unitiol).
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