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  • Title: [Risk factors of death and hospitalization due to pneumonia. Results from the Osterbro study].
    Author: Lange P, Vestbo J, Nyboe J.
    Journal: Ugeskr Laeger; 1997 Feb 10; 159(7):956-9. PubMed ID: 9054088.
    Abstract:
    The aim of this study was to identify possible risk indicators for pneumonia leading to death and hospitalisation in the general population. We followed 6,158 men and 7,265 women aged 30-70 years, who participated in the Copenhagen City Heart Study, a prospective population study, for approximately 12 years with regard to mortality and hospital admissions for pneumonia. A total of 260 deaths with pneumonia as main or contributory death cause had occurred, and 405 subjects had been admitted to hospital at least once because of pneumonia. Mortality and hospitalisation were analysed by multivariate Cox regression models. In addition to increasing age, forced expiratory volume in 1 second (FEV1) was strongly and consistently related to both pneumonia related mortality and hospitalisation. Women with FEV1 < 60% predicted had a relative risk of 5.7 (95% confidence interval: 2.9-11) and 3.6 (2.2-6.4) for death and hospitalisation, respectively, when compared to women with FEV1 > or = 100% predicted. Similar although lower relative risks were observed in men. Other significant risk indicators for hospitalisation were: self-reported asthma (women), mucus hypersecretion (women and men), history of stroke (men) and smoking (women). We conclude that, in addition to age, reduced FEV1 is the most important risk indicator for severe pneumonia.
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