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  • Title: Iris juvenile xanthogranuloma studied by immunohistochemistry and flow cytometry.
    Author: Shields JA, Eagle RC, Shields CL, Collins ML, DePotter P.
    Journal: Ophthalmic Surg Lasers; 1997 Feb; 28(2):140-4. PubMed ID: 9054486.
    Abstract:
    An unusual large tan iris mass in a 19-month-old child was removed by iridocyclectomy and studied by light microscopy, immunohistochemistry, and flow cytometry. The excised mass consisted of granulomatous inflammation with numerous osteoclast-like giant cells and scattered atypical Touton giant cells. Immunohistochemistry studies showed that the cells were most consistent with mononuclear histiocytes. Flow cytometry showed that 90% of the cells sampled were T-lymphocytes, with a predominance of T-suppresser cytotoxic cells. Juvenile xanthogranuloma (XG) of the iris can occur as a large solitary mass, without signs of intraocular inflammation or hyphema.
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