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  • Title: Pharmacokinetics of sulphadimethoxine in cattle.
    Author: Boxenbaum HG, Fellig J, Hanson LJ, Snyder WE, Kaplan SA.
    Journal: Res Vet Sci; 1977 Jul; 23(1):24-8. PubMed ID: 905649.
    Abstract:
    Four healthy Angus steers received a single rapid intravenous injection of sulphadimethoxine at a dose of approximately 55 mg/kg. The elimination half-life determined from plasma concentration-time data was approximately 12-5 h, and the volume of distribution was 31-0 per cent of body weight. Animals also received sulphadimethoxine intravenously or orally at a loading dose of approximately 55 mg/kg, followed by sustaining oral doses of approximately 27-5 mg/kg at 24, 48 and 72 h. It was demonstrated that oral maintenance doses served to sustain sulphonamide plasma concentrations achieved with the loading dose.
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