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  • Title: Dynamic contrast-enhanced FMPSPGR of the pancreas: impact on diagnostic performance.
    Author: Göhde SC, Toth J, Krestin GP, Debatin JF.
    Journal: AJR Am J Roentgenol; 1997 Mar; 168(3):689-96. PubMed ID: 9057517.
    Abstract:
    OBJECTIVE: The objective of this study was to evaluate the diagnostic impact of dynamic contrast-enhanced fast multiplanar spoiled gradient-recalled imaging (FMPSPGR) of the pancreas. MATERIALS AND METHODS: MR imaging examinations of the upper abdomen for 101 patients were evaluated retrospectively and compared with histologic and surgical results as well as imaging or laboratory and clinical follow-up results. Standard T1-weighted spin-echo images, T2-weighted fast spin-echo images with fat saturation, and FMPSPGR had been obtained for all patients. Of the 101 patients, 79 also underwent fat-saturated contrast-enhanced T1-weighted spin-echo MR imaging. Qualitative analysis consisted of evaluation of overall image quality and characterization of the pancreas as normal or abnormal, for which receiver operating characteristic curves were calculated. A contrast-to-noise ratio between the pancreas and the surrounding tissue was calculated for each patient. RESULTS: By a statistically significant margin, FMPSPGR performed better than conventional spin-echo MR imaging. For FMPSPGR, sensitivity and specificity were 87% and 100%, respectively, compared with T1-weighted spin-echo sequences (sensitivity, 50%; specificity, 96%), T2-weighted spin-echo sequences with fat saturation (sensitivity, 60%; specificity, 93%), and contrast-enhanced T1-weighted spin-echo sequences with fat saturation (sensitivity, 53%; specificity, 90%). Diagnostic confidence was highest with FMPSPGR. CONCLUSION: FMPSPGR should be used in all MR imaging examinations of the upper abdomen. This technique offers better visualization of important structures and increases confidence for a more specific and accurate diagnosis than does conventional spin-echo imaging.
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