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  • Title: IgG1 subclass restriction of oligoclonal measles virus-specific IgG antibodies in patients with subacute sclerosing panencephalitis and in a patient with multiple sclerosis.
    Author: Vandvik B, Natvig JB, Norrby E.
    Journal: Scand J Immunol; 1977; 6(6-7):651-7. PubMed ID: 905776.
    Abstract:
    A restriction to the IgG1 subclass was demonstrated for measles virus-specific IgG antibodies isolated from the sera of five patients with subacute sclerosing panencephalitis, from the cerebrospinal fluid of one of the patients, and from brain extract from a sixth patient. A predominance of IgG1 was also observed in measles antibodies isolated from the serum and brain extract of a patient with multiple sclerosis. Evidence is presented that the IgG1 restriction is associated with the occurrence of oligoclonal measles antibodies in these patients. A similar restriction to the IgG1 subclass was not observed in measles antibodies isolated from the serum of a measles-convalescent child or from pooled normal serum and IgG.
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