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  • Title: In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium.
    Author: Asahara H, Hasunuma T, Kobata T, Inoue H, Muller-Ladner U, Gay S, Sumida T, Nishioka K.
    Journal: J Rheumatol; 1997 Mar; 24(3):430-5. PubMed ID: 9058644.
    Abstract:
    OBJECTIVE: To examine the relationship among the expression of protooncogenes such as c-fos and c-myc, Fas antigen, Fas ligand, and apoptosis in the synovial tissue of patients with rheumatoid arthritis (RA). METHODS: The expression of c-fos, c-myc, Fas antigen, and Fas ligand was examined in synovial tissues of 6 patients with RA and 4 with osteoarthritis (OA) using in situ reverse transcriptase (RT) assay and immunohistochemical staining. Apoptosis was detected by TUNEL method in situ. RESULTS: Expression of protooncogenes, c-fos, and c-myc was detected in all samples from patients with RA, but in only a few cells of OA synovium. 30 to 90% of cells in RA synovium positive for these protooncogenes also coexpressed Fas antigen. Fas positive cells in RA synovium underwent apoptosis to a significant degree. Fas ligand mRNA was detected only in mononuclear cells in RA synovium. CONCLUSION: The expression of protooncogenes is closely related to Fas mediated apoptosis in RA synoviocytes.
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