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  • Title: Investigation of the influence of the Mm musculus MyoD1 allele on the efficiency of skeletal muscle regeneration.
    Author: Marlow SA, Kay PH, McGeachie JK, Papadimitriou JM.
    Journal: J Anat; 1997 Feb; 190 ( Pt 2)(Pt 2):223-7. PubMed ID: 9061445.
    Abstract:
    MyoD1 alleles distinguish between the Mm musculus and Mm domesticus subspecies of Mus musculus. SJL/J mice, which belong to the Mm musculus subspecies, are able to regenerate skeletal muscle more efficiently than BALB/c mice which possess the Mm domesticus MyoD1 allele. Hence the possibility that regeneration responses are due to species-specific genetic differences including MyoD1 was investigated in this study. Quantitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenotype is not species-specific and may not be directly related to MyoD1 alleles. These results contrast with prior investigations conducted in SJL/J and BALB/c mice, and indicate that other genes may have a direct influence on skeletal muscle regeneration.
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