These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prostanoid excretion in incipient singleton and twin pregnancies.
    Author: van der Weiden RM, Helmerhorst FM, Keirse MJ.
    Journal: Am J Obstet Gynecol; 1996 May; 174(5):1614-7. PubMed ID: 9065139.
    Abstract:
    OBJECTIVE: Our purpose was to examine the urinary excretion of metabolites of prostacyclin, 6-keto-prostaglandin F(1 alpha) and 2,3-dinor-6-keto-prostaglandin F(1 alpha), and thromboxane A2, thromboxane B2 and 2,3-dinor-thromboxane B2, in early twin and singleton pregnancies resulting from in vitro fertilization-embryo transfer. STUDY DESIGN: Overnight urine samples were obtained from 23 women at regular intervals for 20 weeks after embryo transfer. Prostanoids were measured by high-pressure liquid chromatography-radioimmunoassay. RESULTS: All prostanoids, most markedly 6-keto-prostaglandin F(1 alpha) and 2,3-dinor-6-keto-prostaglandin F(1 alpha), increased in both singleton and twin pregnancies. This resulted in an increased ratio of prostacyclin over thromboxane A2 both in the dinor compounds (from 1.3 to 2.8) and the total metabolites (from 1.7 to 3.5). No marked differences were observed between twin and singleton pregnancies. CONCLUSIONS: Twin and singleton pregnancies show a similar increase in the prostacyclin to thromboxane A2 ratio in the first half of pregnancy.
    [Abstract] [Full Text] [Related] [New Search]