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  • Title: Detection of polymorphisms in the human urokinase-type plasminogen activator gene.
    Author: Conne B, Berczy M, Belin D.
    Journal: Thromb Haemost; 1997 Mar; 77(3):434-5. PubMed ID: 9065988.
    Abstract:
    Expressed polymorphisms in the genes encoding components of the fibrinolytic cascade could have implications for the predisposition to thrombolytic disorders and/or for tumor metastasis. The occurrence of published two amino acid sequences at position 194 of the human urokinase-type plasminogen activator prompted us to search by SSCP for frequent polymorphisms in several exons of the gene. Surprisingly, only one sequence was detected in codon 194 (> 200 alleles). Two polymorphisms were observed in this study: the most frequent one, a C to T change near the beginning of exon 8, is probably silent; a less frequent polymorphism results in the replacement of a Leu residue by a Pro, in the kringle domain.
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