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  • Title: Cis-urocanic-acid-induced suppression of contact hypersensitivity in Monodelphis domestica is prevented by ultraviolet A radiation/photoreactivating light.
    Author: Reeve VE, Ley RD.
    Journal: Int Arch Allergy Immunol; 1997 Mar; 112(3):257-61. PubMed ID: 9066512.
    Abstract:
    The suppression of contact hypersensitivity by UVB (280-320 nm) radiation can be prevented by photoreactivating light (PRL; 320-400 nm) in the opossum Monodelphis domestica, implicating epidermal DNA lesions as the immunosuppressive impairment. However, contact hypersensitivity can also be suppressed in the opossum with exogenous cis-urocanic acid, a molecule which is produced in UVB-irradiated epidermis and is a second potential mediator of photo-immunosuppression apparently independent of UVB-induced DNA damage. Here we demonstrate that irradiation of opossums with PRL either before or following treatment with exogenous cis-urocanic acid, significantly reduced the degree of immunosuppression. This suggests that, in addition to its capacity to initiate post-UVB-exposure epidermal DNA repair, the PRL waveband can induce an immunoprotective product, as yet unidentified, in opossum epidermis.
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