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  • Title: Colorectal cancer after pelvic irradiation: case reports.
    Author: Tsunoda A, Shibusawa M, Kawamura M, Marumori T, Kusano M, Ohta H.
    Journal: Anticancer Res; 1997; 17(1B):729-32. PubMed ID: 9066610.
    Abstract:
    Four patients with colorectal cancer after pelvic irradiation for gynaecological malignancies are reported. The interval between irradiation and the diagnosis of colorectal cancer was 15-28 years. Histological findings of radiation proctocolitis adjacent to the cancer were observed in all specimens. Ki-67 immunohistologic staining showed high cell proliferation activity in the irradiated mucosa of a recently removed specimen. Although irradiation has not been proved to induce colorectal cancer, considerable circumstantial evidence supports this belief. Awareness of this potential long-term complication is important when planing the follow-up of patients subjected to pelvic radiotherapy.
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