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  • Title: Enhancement of UV-A-induced cytotoxicity to cancer cell lines by camptothecin.
    Author: Kojima S, Fujishima H, Wang DS.
    Journal: Anticancer Res; 1997; 17(1A):241-6. PubMed ID: 9066659.
    Abstract:
    The exposure of cultured mouse melanoma (B-16) cells, to camptothecin (CAM) after irradiation of the cells with UV-A synergistically enhanced cytotoxicity. CAM treatment prior to irradiation had the same effect. Similar results were also obtained with the combination of gamma-ray irradiation and CAM in this model. Thus, the sensitivity of the cells to UV-A and gamma-ray irradiation was significantly elevated by CAM. These findings have potential clinical utility.
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