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  • Title: Role of dopamine D1- and NMDA receptors in regulating neurotensin release in the striatum and nucleus accumbens.
    Author: Wagstaff JD, Gibb JW, Hanson GR.
    Journal: Brain Res; 1997 Feb 14; 748(1-2):241-4. PubMed ID: 9067469.
    Abstract:
    Stimulation of dopamine D1-receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D1-receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT release induced by D1-stimulation in both structures. Tissue content of striatal NT anterior and posterior to the microdialysis probe was oppositely altered by D1-stimulation: increases were observed in the anterior striatum with decreased NT levels in the posterior striatum.
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