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  • Title: Protein kinase C does not mediate the dopamine-dependent modulation of glutamate receptors in retinal horizontal cells of the perch (Perca fluviatilis).
    Author: Schmidt KF.
    Journal: Vision Res; 1996 Dec; 36(24):3939-42. PubMed ID: 9068847.
    Abstract:
    The whole-cell patch-clamp technique was employed to record membrane currents from cultured horizontal cells of the perch (Perca fluviatilis). The cells were voltage clamped and slowly superfused with an extracellular solution containing L-glutamate. The glutamate concentration in the bath was continuously measured with the help of photodiode and a dye which accumulated in the bath together with the agonist. The PKA-activator forskolin mimicked the effect of dopamine and enhanced glutamate-induced currents, while application of the PKC stimulator PMA or the synthetic diacylglycerol analogue OAG had no significant effects on the dose-response curves of glutamate induced-currents. These results may indicate that the modulation of glutamate receptors in fish horizontal cells is not mediated via a PKC-dependent pathway.
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