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  • Title: Augmented expression of the endothelin-A receptor gene in cultured mesangial cells from stroke-prone spontaneously hypertensive rats.
    Author: Hiraoka J, Arai H, Yoshimasa T, Takaya K, Miyamoto Y, Yamashita J, Suga S, Ogawa Y, Shirakami G, Itoh H.
    Journal: Clin Exp Pharmacol Physiol Suppl; 1995 Dec; 22(1):S191-2. PubMed ID: 9072350.
    Abstract:
    1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied the expression of the ET-A receptor (ET-AR) gene and the ET-B receptor (ET-BR) gene in cultured mesangial cells isolated from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats. 2. The mesangial cells from both SHRSP and WKY expressed ET-AR predominantly. The level of the ET-AR mRNA in mesangial cells from SHRSP was 5-fold higher than that in the cells from WKY. The ET-BR mRNA in the mesangial cells from both strains was hardly detectable by northern blot analysis. 3. These results demonstrate that the expression of the ET-AR gene was markedly augmented in mesangial cells from SHRSP.
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