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  • Title: Comparison of immunofiltration assay of plasma D-dimer with diagnostic imaging in deep vein thrombosis.
    Author: Killick SB, Pentek PG, Mercieca JE, Clarke MF, Bevan DH.
    Journal: Br J Haematol; 1997 Mar; 96(4):846-9. PubMed ID: 9074429.
    Abstract:
    This prospective study was designed to assess the diagnostic sensitivity, specificity and negative predictive value of the NycoCard D-dimer plasma immunofiltration assay in patients with suspected deep vein thrombosis (DVT) confirmed by ultrasonography/venography. 84 medical patients were recruited: 43 patients (51%) had proven venous thrombosis, 33 by venography and 10 by ultrasonography. The sensitivity of NycoCard D-dimer in patients with DVT was 95.3%, the specificity was 22.0% and the negative predictive value was 81.8%. An algorithm including the NycoCard D-dimer test for the acute management of DVT is proposed. This would enable low-risk patients to be discharged early from hospital, without imaging or anticoagulant therapy.
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