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  • Title: Hemostasis in newborns of smoking and nonsmoking mothers.
    Author: Mercelina-Roumans PE, Ubachs JM, van Wersch JW.
    Journal: Am J Obstet Gynecol; 1997 Mar; 176(3):662-6. PubMed ID: 9077625.
    Abstract:
    OBJECTIVE: Our purpose was to determine the effect of smoking during pregnancy on neonatal hemostasis. STUDY DESIGN: Venous blood samples of 26 newborns of smoking and 25 newborns of nonsmoking mothers were obtained from the clamped umbilical cord immediately after birth. Prothrombin fragment 1+2, thrombin-antithrombin III complex, plasmin-alpha2-antiplasmin complex, and D-dimer levels were determined to assess activation of coagulation and fibrinolysis. Cotinine was measured in all neonates to objectify cigarette smoke exposure. The Mann-Whitney U test was used to compare the differences between the values of the parameters of coagulation and fibrinolysis in the two groups at the p < 0.05 level. RESULTS: The median values of prothrombin fragment 1+2 and thrombin-antithrombin III complex in newborns exposed to tobacco smoke in utero did not differ from values of newborns who were not exposed. Nor were the markers of fibrinolysis, plasmin-alpha2-antiplasmin complex and D-dimer levels, influenced by tobacco smoke exposure. CONCLUSION: The balance between the components of coagulation and fibrinolytic pathways in neonates is not disturbed by maternal smoking.
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