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  • Title: Movement kinematics encoded in complex spike discharge of primate cerebellar Purkinje cells.
    Author: Fu QG, Mason CR, Flament D, Coltz JD, Ebner TJ.
    Journal: Neuroreport; 1997 Jan 20; 8(2):523-9. PubMed ID: 9080441.
    Abstract:
    Monkeys performed a multijoint arm-reaching task that systematically varied movement direction and distance. Purkinje cell activity was recorded from 231 task-related cells, and the complex spike discharge was analyzed in relation to distance and direction. The complex spike activity of 123 Purkinje cells changed significantly relative to the background rate. Of these 123, the activity of 85 cells was related to distance and/or direction. The complex spike activity of 54 of these 85 cells fitted a cosine tuning curve for direction, generally at one distance. Using a simple linear regression model, the complex spike activity of 56 cells was significantly correlated with movement distance, usually in one direction. We conclude that the complex spike discharge of Purkinje cells is spatially tuned and strongly related to movement kinematics.
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