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  • Title: Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.
    Author: Reddy BS, Watanabe K, Weisburger JH.
    Journal: Cancer Res; 1977 Nov; 37(11):4156-9. PubMed ID: 908050.
    Abstract:
    Male inbred F344 weanling rats were fed semipurified diets containing 20 or 5% beef fats. At 7 weeks of age, all animals except controls were given 1,2-dimethylhydrazine [DMH (150 mg/kg body weight s.c.; one dose)], methylazoxymethanol acetate [MAM acetate (35 mg/kg body weight i.p.; one dose)], or methylnitrosourea (2.5 mg/rat/week intrarectally; two doses), and autopsied 35 weeks later. No major differences were observed in the frequency (number of rats with tumor) of DMH- or MAM acetate-induced duodenal, ear duct, and kidney tumors between the rats fed diets containing 20 or 5% fat. However, the animals fed the diet containing 20% fat had slight although not statistically significant influence on the incidence of adenomas and adenocarcinomas in the colon.
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