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  • Title: Changes in plasma prolactin and catecholamine metabolite levels following acute needle stick in children.
    Author: Grayson RH, Halperin JM, Sharma V, Schwartz ST, Koda VH, Newcorn JH.
    Journal: Psychiatry Res; 1997 Mar 03; 69(1):27-32. PubMed ID: 9080542.
    Abstract:
    Changes in plasma levels of prolactin (PRL), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) following insertion of an indwelling catheter into a forearm vein were assessed in 11 boys with attention-deficit hyperactivity disorder. Results indicated decreases in plasma PRL and HVA, but not MHPG, from the time of needle stick until 105 min post-insertion. These data indicate a significant increase in plasma PRL and HVA in children following needle stick which gradually decreases over a 1.5-2-h period. These stress-induced changes indicate that values obtained immediately after needle insertion cannot be assumed to accurately reflect baseline levels.
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