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  • Title: [Comparison of serum concentrations of once and twice daily administration of ultra-retard theophylline in school children with bronchial asthma].
    Author: Liebke C, Niggemann B, Wahn U.
    Journal: Pneumologie; 1996 Nov; 50(11):752-5. PubMed ID: 9082442.
    Abstract:
    It was the aim of our study to find out whether once-daily administration of an ultra-retard preparation is meaningful also during childhood if compared to twice-daily application. To this end we examined 11 children (6 girls, 5 boys) between 7 and 16 years of age (median 12 years) who were suffering from bronchial asthma. The same theophylline daily dose was administered for 10 days each either as a single dose in the evening (20.00 hrs) or subdivided into two single doses (9.00 and 20.00 hrs). Dosage was according to age between 11 and 24 mg/kg body weight and day. The median values of blood serum concentration of theophylline of the once-daily or twice-daily administration in the "steady state" did not show any significant difference in the course of the 24-hour observation. The maximum effective concentration was attained after 12 hours in case of the once-daily application and after 8 hours with the twice-daily application. Summing up, our data indicate that good control of asthma bronchiale can be achieved even with once-daily administration of an ultra-retard preparation also in childhood. With both regimens the blood serum concentrations showed a satisfactorily low variability over 24 hours.
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