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  • Title: The effect of cimetidine versus ranitidine on the gastric emptying rate of intensive care unit patients sustained on artificial respiration.
    Author: Pelfrene E, Vandewoude K, Vogelaers D, Elewaut A, Colardyn F.
    Journal: Acta Gastroenterol Belg; 1996; 59(4):229-33. PubMed ID: 9085622.
    Abstract:
    OBJECTIVE: To answer the question if their is a difference between cimetidine versus ranitidine on the gastric emptying rate. DESIGN: Prospective, blinded, randomised controlled study. SETTING: A mixed intensive care unit at the University Hospital. PATIENTS: Twenty-four patients sustained on artificial respiration. INTERVENTIONS: Blinded and randomised either cimetidine 200 mg or ranitidine 50 mg were administered IV, after administration of 500 ml of enteral nutrition. MAIN OUTCOME MEASURES: The gastric emptying rate (gastric filling index) was measured over 120 minutes by an ultrasonographic method. In both groups t/2 was very long, there was no statistical difference between the two groups concerning the mean gastric filling index values at successive measurements (time 0 to 120 minutes). Neither was there a difference between the young and the elderly, female and male patients. CONCLUSION: Following administration of either ranitidine or cimetidine in bolus, no difference in the gastric emptying of gastric liquid feeding could be observed in critically ill intubated, ventilated patients.
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