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  • Title: Efficacy of two avian Salmonella-immune lymphokines against liver invasion in chickens by Salmonella serovars with different O-group antigens.
    Author: Ziprin RL, Kogut MH.
    Journal: Avian Dis; 1997; 41(1):181-6. PubMed ID: 9087335.
    Abstract:
    Newly hatched chicks are susceptible to organ invasion by various serovars of Salmonella. We have previously shown that intraperitoneal administration of Salmonella enteritidis-immune lymphokine (SEILK) increased resistance to organ invasion by S. enteritidis (SE) in day-of-hatch chicks. In the present study, we determined that Salmonella-immune lymphokines can provide protection against organ invasion by serovars that are unrelated to the original serovar used as an immunogen. Immune lymphokines were produced from the splenic T cells of mature hens immunized with either viable SE or Salmonella anatum (SA). Day-of-hatch chicks were treated with either SA-immune lymphokine (SAILK) or SEILK and challenged per os with either Salmonella typhimurium (ST) or SE 1 hr later. Liver samples were aseptically collected 20 hr later and were cultured to detect salmonella. We found that SAILK conferred resistance against invasion by either SE, a serogroup D organism, or ST, a serogroup B organism. Furthermore, SEILK reduced organ invasion by ST. These observations together reveal that the protection against organ invasion conferred by Salmonella-immune lymphokines is unrelated to the serovar-specific antigenic characteristics of the immunizing bacteria.
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