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  • Title: Focal brain dysfunction in a 41-year old man with familial alternating hemiplegia.
    Author: Dangond F, Garada B, Murawski BJ, Rey-Casserly C, Holman BL, Mikati MA.
    Journal: Eur Arch Psychiatry Clin Neurosci; 1997; 247(1):35-41. PubMed ID: 9088804.
    Abstract:
    The acute pathophysiologic changes during hemiplegic spells and the long-term outcome of alternating hemiplegia remain obscure. In a 41-year-old male with familial alternating hemiplegia we found an increase in right frontal cerebral blood flow 3 h into a 5-h left hemiplegic episode. A repeat high-resolution brain SPECT study performed 26 h after the resolution of the left hemiplegia revealed normalization of the frontal blood flow accompanied by hyperperfusion in the right parietal lobe. An interictal SPECT scan several weeks later showed no asymmetries. Head CT and MRI scans were negative. Neuropsychologic assessment and neurologic examination revealed evidence of a diffuse disorder which predominantly involved the right hemisphere. To our knowledge, there are no previous correlative studies of serial high-resolution brain SPECT with MRI, or of detailed neuropsychologic assessment, in adult patients with such an advanced course of alternating hemiplegia of childhood.
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