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  • Title: The effect of hormone replacement therapy on vitamin E status in postmenopausal women.
    Author: Wen Y, Doyle MC, Harrison RF, Feely J.
    Journal: Maturitas; 1997 Mar; 26(2):121-4. PubMed ID: 9089561.
    Abstract:
    OBJECTIVES: Vitamin E (alpha-tocopherol) is the most important dietary antioxidant found in lipids and cell membranes and its intake is inversely related to the incidence of atherosclerotic cardiovascular disease. Oestrogen-containing oral contraceptives may decrease plasma vitamin E level in young women. We investigated if oestrogen-containing hormone replacement therapy (HRT) may have the same effect on vitamin E status in postmenopausal women METHODS: Eighteen healthy postmenopausal women took a combination of oestrogen/progestogen (Harmogen Provera) therapy and another ten acted as a control group. Blood samples were taken at baseline and repeated after 3 and 6 months in both groups. Vitamin E in plasma, red cells and isolated low-density lipoprotein (LDL) was measured as alpha-tocopherol by high-performance liquid chromatography. RESULTS: Vitamin E status showed no change in either group after 3 and 6 months in comparison to its baseline value. CONCLUSION: Combined oestrogen/progestogen HRT for 6 months in healthy postmenopausal women did not alter vitamin E. status in vivo.
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