These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Relationships, among the steroids, of anti-inflammatory properties and inhibition of prostaglandin production and arachidonic acid release by transformed mouse fibroblasts.
    Author: Tam S, Hong SC, Levine L.
    Journal: J Pharmacol Exp Ther; 1977 Oct; 203(1):162-8. PubMed ID: 909050.
    Abstract:
    Anti-inflammatory steroids inhibit the serum-stimulated prostaglandin synthesis and release of [3H]arachidonic acid by methylcholanthrene-transformed mouse fibroblast, MC5-5. The half-maximal concentration for inhibition of both effects parallels the relative anti-inflammatory potencies of these steroids. The fatty acid cyclooxygenase activities of microsomal fractions isolated from cells that had been pretreated with dexamethasone were similar to the activities of microsomal fractions isolated from untreated cells. Intracellular as well as extracellular levels of prostaglandins in dexamethasone inhibited cells were decreased. The anti-inflammatory steroids seem to be blocking deacylation of the phospholipids or transport of the arachidonic acid, after deacylation to the cyclooxygenase.
    [Abstract] [Full Text] [Related] [New Search]