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  • Title: [Influence of anemia on hemodynamic changes in patients with cirrhosis].
    Author: Denié C, Poynard T, Gadano A, Vachiery F, Soupison T, Elman A, Valla D, Moreau R, Lebrec D.
    Journal: Gastroenterol Clin Biol; 1997; 21(1):29-33. PubMed ID: 9091387.
    Abstract:
    OBJECTIVE: The aim of this retrospective study was to evaluate the systemic and splanchnic hemodynamic changes induced by anemia in patients with cirrhosis. METHOD: 148 patients (Child-Pugh A: 46 patients, Child-Pugh B: 64 patients and Child-Pugh C: 38 patients) were included in the study. Anemia was defined by a blood hemoglobin level < 12 g/dL. A systemic and splanchnic hemodynamic study was performed in all patients. RESULTS: A significant elevation of the hepatic venous pressure gradient was observed in Child-Pugh A patients with anemia but not in Child-Pugh B and C patients. In the 2 latter groups, cardiac index was significantly increased and systemic vascular resistance decreased in patients with anemia. CONCLUSION: Anemia may worsen the hemodynamic changes associated with cirrhosis.
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