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  • Title: [Antithrombotic therapy in patients with mechanical valve prostheses].
    Author: Roudaut R, Lorient-Roudaut MF.
    Journal: Arch Mal Coeur Vaiss; 1996 Nov; 89(11 Suppl):1543-50. PubMed ID: 9092416.
    Abstract:
    Mechanical valvular prostheses have the advantage of longevity but carry a risk of thrombosis which is itself dependent on many haemodynamic, haemostatic and parietal factors. Antithrombotic therapy in patients with mechanical valvular prostheses is based on vitamin-K antagonists, the optimal dosage of which should reflect the type and location of the prosthesis and the underlying pathology. The patient with a mechanical valvular prosthesis treated by oral anticoagulation must be fully informed and regularly followed up. Special situations: extracardiac surgery, dental extraction, gastrointestinal endoscopy, require specific, well established management.
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