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  • Title: [Intravenous anesthesia by continuous administration of midazolam and fentanyl].
    Author: Yoshida Y, Misaki T, Takada K, Kyoda N, Kunimatsu T, Kanayama T.
    Journal: Masui; 1997 Mar; 46(3):326-30. PubMed ID: 9095603.
    Abstract:
    We examined the amount and method of administration of midazolam and fentanyl for intravenous anesthesia. Intravenous anesthesia was induced by intravenous administration of fentanyl 0.2-0.3 mg, followed by a minimal sleeping-inducing dose of midazolam, and then an additional 0.2 mg of fentanyl before starting the operation. To maintain anesthesia, a half dose of the first dose of midazolam was administered every hour, and a continuous intravenous injection of fentanyl at 0.08 microgram-1. kg-1.min-1 was also performed. It is suggested that these doses are the most suitable for obviating the use of antagonist. Also, by using a continuous administration, the dose of fentanyl can be reduced, and it is possible to stabilize circulation. Without the use of nitrous oxide during intravenous anesthesia, it is necessary to double the dose of fentanyl administered.
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