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  • Title: Phenobarbital prophylaxis of neonatal hyperbilirubinemia. Evaluation of a nightly dose.
    Author: Thomas CR.
    Journal: Obstet Gynecol; 1977 Nov; 50(5):607-10. PubMed ID: 909669.
    Abstract:
    In an attempt to improve the success of a previous study of the prevention of neonatal hyperbilirubinemia employing phenobarbital in a single 30-mg nightly dose from 32 weeks' gestation until delivery, 246 patients were tested against 270 control subjects. A 39% reduction in significant hyperbilirubinemia was realized but this fell far short of previous findings with a larger dose. Premature infants received no apparent protection against jaundice. Mature infants had no severe jaundice (more than 16 mg/100 ml) and the resolution of hyperbilirubinemia was more rapid. No apparent difference in drowsiness or daytime sedation from previous experience was found. Female newborns responded much better (3:1) to prophylaxis. These disappointing results favor a return to the 1-g daily divided dose.
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